Changes of PSA concentrations in serum and saliva of healthy women during the menstrual cycle.

نویسندگان

  • Hülya Aksoy
  • Fatih Akçay
  • Zühal Umudum
  • A Kadir Yildirim
  • Ramazan Memisogullari
چکیده

This study investigated the changes of prostate specific antigen (PSA) concentrations in serum and saliva of women during the menstrual cycle. Thirty healthy volunteers (age 23-35 yr) were enrolled in the study. During the menstrual cycle, serum and saliva PSA concentrations on days 9 (follicular phase) and 14 (mid-cycle) were significantly higher than on days 4 (early follicular phase) and 21 (luteal phase). The expected changes in gonadal hormones were seen, as evidenced by significantly higher serum estradiol and progesterone concentrations during the midcycle and luteal phase, compared to the other phases of the cycle. Serum PSA concentrations were positively correlated with salivary PSA concentrations at all 4 times (days 4, 9, 14, and 21) of the menstrual cycle, but not with the serum progesterone or estrogen concentrations. This study suggests that salivary PSA, rather than being produced in the salivary gland, may reflect the serum PSA during the normal menstrual cycle.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Prostate-specific antigen in serum during the menstrual cycle.

We previously found that prostate-specific antigen (PSA) expression in the female breast is regulated by steroid hormones and their receptors. We have now examined whether the PSA concentration in serum changes during the menstrual cycle of healthy women. Among 14 women studied, 3 had serum PSA > or = 4 ng/L; their changes in PSA content during the menstrual cycle were studied in 7 informative ...

متن کامل

The influence of hormonal changes during menstrual cycle on serum adiponectin concentrations in healthy women.

Adiponectin is an adipocyte-derived hormone involved in the regulation of carbohydrate and lipid metabolism. Its concentrations are decreased in patients with obesity, type 2 diabetes and atherosclerosis and are higher in females than in males. Gender differences of adiponectin levels raise the possibility that sex hormones directly regulate its serum concentrations, which may in turn influence...

متن کامل

Correlation between serum and un-stimulated whole saliva c-erbB-2 concentrations in women with breast cancer

Correlation between serum and un-stimulated whole saliva c-erbB-2 concentrations in women with breast cancer   Dr. Agha-Hosseini F.,1 Dr. Mirzai-Dizgah E.,2 Dr. Rahimi A.3 1Professor, Department of Oral Medicine. Dental Research Center, School of Dentistry, Medical Sciences / University of Tehran, Tehran, Iran. 2Assistant professor, Department of Physiology, School of Medicine, Army University ...

متن کامل

تغییرات میل جنسی در سیکل قاعدگی و ارتباط آن با سندرم پیش از قاعدگی

Background: Sexual function in women may be affected by their menstrual cycle. Lack of sexual drive is a deficiency or absence of sexual fantasies and desire for sexual activity. This study aims at determining the changes in sexual desire during the menstrual cycle and those associated with premenstrual syndrome (PMS) and evaluates sexual desire during the menstrual cycle and the associated cha...

متن کامل

P-162: Pathophysiology of Endometriosis is Interacted by MIF, its Receptor and COX-2

Background: Endometriosis is a gynecological disease associated with severe pelvic pain and infertility. Immunological changes that occur in patients with endometriosis include reduced natural killer cell and T-lymphocyte cytotoxicity in the peritoneal fluid, and an elevated number of activated macrophages. MIF via its receptor, CD74, initiates a signaling cascade that leads to proliferation an...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Annals of clinical and laboratory science

دوره 32 1  شماره 

صفحات  -

تاریخ انتشار 2002